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KMID : 0379520030190040293
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한국독성학회지
2003 Volume.19 No. 4 p.293 ~ p.296
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Cytotoxic Activity of the Extracts from Curcuma zedoaria
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Kim Myoun-Gae
Kim Jung-Sun
Hong Jong-Ki
JI Ming-Jie
Lee Yong-Kyu
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Abstract
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The effect of the hexane extract of Curcuma zedoaria roots and its solvent fractions were investigated on the proliferation of SiHa, SNU-1 and HepG2 cell lines. Among those fractions, final fraction H2-3-1 and H2-3-3 showed cytotoxic effect on SiHa and HepG2 cell lines. The hallmark of apoptosis, DNA fragmentation, also appeared in the final fractions H2-3-1 and H2-3-3 after 24h treatment in SiHa cell line. Furthermore, those fractions were shown to be able to induce cell death in [^3H]thymidine incorporation test. These two fractions, H2-3-1 and H2-3-3 were determined as (-)-alpha-curcumene and beta-tumerone respectively by NMR and mass spectrum. From these results, it is speculated that te hexane extract of Curcuma zedoaria is necessary for further studies as a potent inhibitor of the growth of cancer cells.
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KEYWORD
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Curcuma zedoaria roots, Hexane fraction, SiHa cells, Cytotoxicity, DNA fragmentation, Apoptosis inducer.
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